PUBBLICAZIONI SCIENTIFICHE

Di seguito sono riportati, in ordine cronologico, i link ad articoli scientifici rilevanti sulla Malattia di Lafora pubblicati sul sito PUB MED. ed altri.
Essendo testi di carattere scientifico e internazionale, per evitare inesattezze, gli stessi vengono proposti senza traduzione in Italiano. Chi avesse difficoltà nella traduzione può richiederla via e-mail all'Associazione.

Data Argomento
15-Apr-2013 Inhibiting glycogen synthesis prevents lafora disease in a mouse model.pdf
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20-Giu-2012 Increased laforin and laforin binding to glycogen underlie Lafora body formation in malin-deficient Lafora disease
28-Apr-2011 PTG Depletion Removes Lafora Bodies and Rescues the Fatal Epilepsy of Lafora Disease
13-Apr-2011 Glycogen Hyperphophorylation Underlies Lafora Body Formation
25-Nov-2008 The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system
01-Giu-2008 Laforin confers cancer resistance to energy deprivation-induced apoptosis.
29-Feb-2008 Lafora disease in the Indian population: EPM2A and NHLRC1 gene mutations and their impact on subcellular localization of laforin and malin.
10-Dic-2007 Malin Decreases Glycogen Accumulation by Promoting the Degradation of Protein Targeting to Glycogen (PTG).
04-Dic-2007 Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.
20-Nov-2007 Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway.
21-Ott-2007 Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy.
23-Lug-2007 The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease.
02-Mar-2007 Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.